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All-flash arrays are now commonplace in today's data centers, and understanding how to configure and manage VMware vSphere to take advantage of them, in both performance and capacity, is critical. The concept of all-flash and, in particular data reduction, changes how some traditional options inside of VMware ESXi should be considered. Topics such as queuing, space reclamation, Storage I/O Control, VMware vSphere Storage DRS, VMware vSphere VMFS 6, virtual disk choice, multipathing, quality of service, and more will discussed.